A study was done in a rehabilitative hospital in the Gunma prefecture in Japan, with 50 patients in an experimental group and 50 patients used as a control. All patients suffered from cerebrovascular diseases causing senility, Parkinson's disease, or other spinocerebellar and orthopedic diseases that afflict the elderly. Seven of the patients in the experimental group suffered from different types of dementia. The patients in this group received 5g of dried Lion's Mane Mushroom per day in their soup for a 6-month period. All patients were evaluated
before and after the treatment period for their Functional Independence
Measure (FIM), which is a measure of independence in physical capabilities
(eating, dressing, walking, etc) and perceptual capacities (understanding,
communication, memory, etc).
The results of this preliminary study show that after six months of taking Lion's Mane Mushroom, six out of seven Alzheimer's patients demonstrated improvements in their perceptual capacities, and all seven had improvements in their overall FIM score.
In 1991, a novel class of compounds in Lion's Mane, called "hericenones",
was discovered by Dr. Hirozaku Kawagishi of Shizuoka University in Japan.
These "hericenones" were found to stimulate the production of
Nerve Growth Factor (NGF) in mouse astraglial cells in culture. Dr. Kawagishi
saw the possibility of using this novel compound as a natural treatment
for Alzheimer's disease. He speculated that if they could cross the blood-brain
barrier and induce NGF production in the brain, this might counteract some
of the neurodegenerative effects of Alzheimer's disease. Massive neuronal
cell death is the ultimate outcome of Alzheimer's disease, so NGF production
might conceivably lead to the growth of new neurons to replace those that
die.
Dr. Kawagishi's continuing work on "hericenones" led him to pursue
more deeply the mechanism by which damage is done in Alzheimer's disease.
As the disease progresses, there is destruction of neurons caused by the
formation of plaques containing a molecule called amyloid beta peptide.
These plaques are toxic to surrounding neurons in the brain. Dr. Kawagishi
discovered that an agent in Lion's Mane Mushroom inhibits the toxicity
of the plaques. He demonstrated that this agent is a phospholipid and can
exert a protective effect on brain cells in culture, shielding them from
damage by the amyloid peptides. This agent is now called Amyloban (Japanese
patent 394,3399).
Therefore, as we have shown, Lion's Mane mushroom contains at least two substances that may be effective in counteracting the damage done to the human brain by diseases such as Alzheimer's -Hericenones and Amyloban.
Maitake Products, Inc., has successfully developed a standardized extract
(PLM-fraction) from Lion's Mane mushroom that contains both of the above
active substances - Hericenones and Amyloban and it is now available from
Shoko's Natural Products (Amyloban 3399, item #4142) with our discounted
price (See the price at the end of this page).
All the drugs approved so far for use against Alzheimer's disease act for a brief period of time by preventing further deterioration in the symptoms of the patient. None of these drugs leads to a consistent improvement in the functional capabilities of the patient. They also have unfavorable side effects.
Limited preliminary clinical studies using Amyloban 3399 indicates promising results against anti-dementia or anti-Alzheimer's disease - some of them are dramatic, and no side effects have been reported (acute and semi-acute toxicity tests were successfully completed).
Shoko's Natural Products recommends those who are already showing symptoms
of Alzheimer's or dementia to use 6 tablets daily of Amyloban 3399 (item #4142) and 4 tablets of Super Lion's Mane
Mushroom (item #4136). For simple prevention, maintenance and good brain
function, we suggest 4-6 tablets per day of Super Lion's Mane Mushroom
alone.
When ordering online please use the pull down arrow menus below for price
breaks on shipping and large quantity orders. Or call us toll free 1-800-654-4394
for accurate quotes to your zip code. Thank you.
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We accept all major credit cards for online orders. You do not need a Pay Pal account to order via the Pay Pal check out system and you do not need to sign up for a Pay Pal account. On every checkout page there is an option to pay using the plain checkout
button. The only other difficulty you may encounter in the checkout process is
if your Credit Card billing address and zip code does not match the address
you entered.
If you would like us to ship to a different address than the one associated with your Credit Card please enter those instructions in the final checkout instruction box. Please call us toll free 1-800-654-4394 if you are having a difficult
time ordering online.
If you are placing an order online for multiple items or large quantities
please call us toll free at 1-800-654-4394 so you will not be overcharged
for shipping. We will however credit your future purchases for any overpayment
on shipping. Should you choose not to call, we will send you an invoice
informing you of any credit to your account.
Shoko's Natural Products recommends those who are already showing symptoms of Alzheimer's or dementia
to use 6 tablets daily of Amyloban 3399 (item #4142) and 4 tablets of Super Lion's Mane Mushroom (item #4136).
For simple prevention, maintenance and good brain function, we suggest 4-6 tablets per day of Super Lion's Mane Mushroom alone.
Mushroom Wisdom Inc © Photographic copyright Anthony Designs ©
Amyloban 3399 Item #4142
180 tablets Our price is $59.45
For additional savings order nine bottles and
save with our large quantity discount pricing.
1-800-654-4394
Shipping quotes apply to USA orders only. If you are ordering from
outside of the USA you will be contacted concerning additional shipping
charges and available shipping options.
All Foreign Orders please click here first.
Shoko's Natural Products recommends those who are already showing symptoms of Alzheimer's or dementia
to use 6 tablets daily of Amyloban 3399 (item #4142) and 4 tablets of Super Lion's Mane Mushroom (item #4136).
For simple prevention, maintenance and good brain function, we suggest 4-6 tablets per day of Super Lion's Mane Mushroom alone.
Mushroom Wisdom Inc © Photographic copyright Anthony Designs ©
Super Lion's Mane Mushroom
Item #4136
120 tablets Our price is $21.99
Please use the pull down arrow menu below for multiple items.
Shipping quotes apply to USA orders only. If you are ordering from
outside of the USA you will be contacted concerning additional shipping
charges and available shipping options.
All Foreign Orders please click here first.
