Anti-Dementia Compounds
from Lion's Mane Mushroom

The focus of research on medicinal mushrooms until now has been primarily on their anti-cancer and immune-enhancing properties. However, attention has shifted by researchers in Japan and China to the potential anti-dementia properties contained in a mushroom called Lion's Mane (Hericium erinacewn).


A study was done in a rehabilitative hospital in the Gunma prefecture in Japan, with 50 patients in an experimental group and 50 patients used as a control. All patients suffered from cerebrovascular diseases causing senility, Parkinson's disease, or other spinocerebellar and orthopedic diseases that afflict the elderly. Seven of the patients in the experimental group suffered from different types of dementia. The patients in this group received 5g of dried Lion's Mane Mushroom per day in their soup for a 6-month period. All patients were evaluated before and after the treatment period for their Functional Independence Measure (FIM), which is a measure of independence in physical capabilities (eating, dressing, walking, etc) and perceptual capacities (understanding, communication, memory, etc).

The results of this preliminary study show that after six months of taking Lion's Mane Mushroom, six out of seven Alzheimer's patients demonstrated improvements in their perceptual capacities, and all seven had improvements in their overall FIM score.

In 1991, a novel class of compounds in Lion's Mane, called "hericenones", was discovered by Dr. Hirozaku Kawagishi of Shizuoka University in Japan. These "hericenones" were found to stimulate the production of Nerve Growth Factor (NGF) in mouse astraglial cells in culture. Dr. Kawagishi saw the possibility of using this novel compound as a natural treatment for Alzheimer's disease. He speculated that if they could cross the blood-brain barrier and induce NGF production in the brain, this might counteract some of the neurodegenerative effects of Alzheimer's disease. Massive neuronal cell death is the ultimate outcome of Alzheimer's disease, so NGF production might conceivably lead to the growth of new neurons to replace those that die.


Dr. Kawagishi's continuing work on "hericenones" led him to pursue more deeply the mechanism by which damage is done in Alzheimer's disease. As the disease progresses, there is destruction of neurons caused by the formation of plaques containing a molecule called amyloid beta peptide. These plaques are toxic to surrounding neurons in the brain. Dr. Kawagishi discovered that an agent in Lion's Mane Mushroom inhibits the toxicity of the plaques. He demonstrated that this agent is a phospholipid and can exert a protective effect on brain cells in culture, shielding them from damage by the amyloid peptides. This agent is now called Amyloban (Japanese patent 394,3399).

Therefore, as we have shown, Lion's Mane mushroom contains at least two substances that may be effective in counteracting the damage done to the human brain by diseases such as Alzheimer's -Hericenones and Amyloban.


Maitake Products, Inc., has successfully developed a standardized extract (PLM-fraction) from Lion's Mane mushroom that contains both of the above active substances - Hericenones and Amyloban and it is now available from Shoko's Natural Products (Amyloban 3399, item #4142) with our discounted price (See the price at the end of this page).

All the drugs approved so far for use against Alzheimer's disease act for a brief period of time by preventing further deterioration in the symptoms of the patient. None of these drugs leads to a consistent improvement in the functional capabilities of the patient. They also have unfavorable side effects.

Limited preliminary clinical studies using Amyloban 3399 indicates promising results against anti-dementia or anti-Alzheimer's disease - some of them are dramatic, and no side effects have been reported (acute and semi-acute toxicity tests were successfully completed).

Shoko's Natural Products recommends those who are already showing symptoms of Alzheimer's or dementia to use 6 tablets daily of Amyloban 3399 (item #4142) and 4 tablets of Super Lion's Mane Mushroom (item #4136). For simple prevention, maintenance and good brain function, we suggest 4-6 tablets per day of Super Lion's Mane Mushroom alone.

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Shoko's Natural Products recommends those who are already showing symptoms of Alzheimer's or dementia
to use 6 tablets daily of Amyloban 3399 (item #4142) and 4 tablets of Super Lion's Mane Mushroom (item #4136).
For simple prevention, maintenance and good brain function, we suggest 4-6 tablets per day of Super Lion's Mane Mushroom alone.


lion's mane mushroom extract amyloban 3399
Mushroom Wisdom Inc Photographic copyright Anthony Designs
Amyloban 3399 Item #4142
180 tablets
Our price is $59.45
For additional savings order nine bottles and
save with our large quantity discount pricing.
1-800-654-4394

Please use the pull down arrow menu below for multiple items.
Shipping quotes apply to USA orders only. If you are ordering from
outside of the USA you will be contacted concerning additional shipping
charges and available shipping options.

All Foreign Orders please click here first.
Amyloban # 4142 + shipping


Shoko's Natural Products recommends those who are already showing symptoms of Alzheimer's or dementia
to use 6 tablets daily of Amyloban 3399 (item #4142) and 4 tablets of Super Lion's Mane Mushroom (item #4136).
For simple prevention, maintenance and good brain function, we suggest 4-6 tablets per day of Super Lion's Mane Mushroom alone.

Super lion's Mane mushroom
Mushroom Wisdom Inc Photographic copyright Anthony Designs
Super Lion's Mane Mushroom
Item #4136
120 tablets Our price is $21.99
Please use the pull down arrow menu below for multiple items.
Shipping quotes apply to USA orders only. If you are ordering from
outside of the USA you will be contacted concerning additional shipping
charges and available shipping options.

All Foreign Orders please click here first.

Lion's Mane # 4136 + shipping

wild lion's mane mushroom

For more information please call Mike or Shoko.
Shoko's Natural Products: Toll Free 1-800-654-4394

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*Disclaimer: All information and products presented through this web site, whether by Shoko's Natural Products or associated manufacturers, have not been evaluated by the United States FDA, and are not intended to diagnose, treat, cure or prevent any disease. The products are neither manufactured nor prescribed for any medical condition. They are manufactured for use as an important addition to your daily life. If you have a health condition, you are advised to seek medical opinions from health professionals before making any changes in your health regimens. The reports and information presented on this website are for information purposes only, not for treatment.



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